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Figure 15: Gouty Destruction at Multiple Finger Joints

J Clin Investig 117(3):636647 Valdez-Morales EE, Overington J, Guerrero-Alba R, Ochoa-Cortes F, Ibeakanma CO, Spreadbury I, Bunnett NW, Beyak M, Vanner SJ (2013) Sensitization of peripheral sensory nerves by mediators from colonic biopsies of diarrhea-predominant irritable bowel syndrome patients: a role for PAR2

With 42.5% of the patients, this is a significantly high prevalence

The dosing context below summarizes published study arms and common research-planning structures

These are observations from preclinical models (rodents) not an effect confirmed in humans, but a research direction on the systemic regulation observed for the peptide