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Hypoxia not only causes the accumulation of immunosuppressive metabolites (such as adenosine and lactic acid) in solid tumors, but also restricts the infiltration of immune cells, thus inhibiting the bodys anti-tumor immune responses
doi: 10.1161/ATVBAHA.118.311022 20 HoferTPLoosdrechtAAvdeStahl-HennigCCassatellaMAZiegler-HeitbrockL
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