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Description
The mechanistic and preclinical evidence sits with the individual peptides chiefly GHK-Cu, which has the deepest literature while the specific three-peptide combination is used in research settings without combination-level trial data

Bilateral simultaneous facial nerve palsy: clinical analysis in seven cases
Possible side effects include injection-site reactions, temporary skin irritation from topical use, and in rare cases, the "copper uglies" phenomenon

doi:10.1016/S0736-0266(03)00110-4 Goldstein AL, Hannappel E, Sosne G, Kleinman HK

This exceptional selectivity profile enables researchers to attribute observed effects specifically to NNMT inhibition, rather than off-target activities that plague less specific compounds
