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Nature 615:151157 Hao Y, Stuart T, Kowalski MH, Choudhary S, Hoffman P, Hartman A, Srivastava A, Molla G, Madad S, Fernandez-Granda C et al (2024) Dictionary learning for integrative, multimodal and scalable single-cell analysis

Changes in sphingolipids Levels of some long-chain hydroxylated and non-hydroxylated sphingolipid species differed between the MPTP and Ctrl groups, with notable differences observed in the GPi and GPe regions of the basal ganglia (Fig

Concerning features may prompt assessment in line with NICE guidelines for suspected cancer (NG12)

3 Macrophage metabolic states and tumor function Macrophage polarization is tightly governed by distinct metabolic programs that determine their effector functions within the tumor microenvironment (38)

Vascular injury and perfusion heterogeneity generate and maintain hypoxia, stabilizing HIF1 and transcriptional programs that upregulate VEGF and CXCL12, thereby promoting angiogenic rebound and recruitment of CXCR4 bonemarrowderived cells after RTprocesses linked to radioresistance and tumor regrowth [112]