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After transferring the methyl group, SAM is converted to S-adenosylhomocysteine (SAH) and hydrolyzed into adenosine and homocysteine

Similarly, coadministration of bupropion (a CYP2D6 inhibitor) with aripiprazole (an active drug metabolized to an inactive metabolite by CYP2D6) may lead to excessively high aripiprazole concentrations, and potential for discontinuation of the treatment due to adverse drug effects (ADEs)

Berberine reduces rat intestinal tight junction injury induced by ischemia-reperfusion associated with the suppression of inducible nitric oxide synthesis

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