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The hereditary spastic paraplegia-related enzyme DDHD2 is a principal brain triglyceride lipase

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This selectivity occurs because AOD-9604 does not bind to growth hormone receptors in muscle tissue and works primarily through beta-3 adrenergic receptors that are predominantly expressed in fat cells
Increased circulating leptin may also enhance lipolysis by counteracting the antilipolytic effects of insulin (86)
