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The zero withdrawal rate in AOD-9604 trials suggests excellent practical tolerability that extends beyond merely counting adverse events to assessing their real impact on treatment continuation

Understanding these metabolic effects has implications for research into diabetes and related metabolic conditions

Genotoxicity evaluation encompassed an Ames mutagenicity evaluation, a chromosomal aberration assay in Chinese hamster ovary (CHO) cells, and a bone micronucleus assay incorporated within a 4-week toxicology study in murine models

References Heffernan M, Summers RJ, Thorburn A, Ogru E, Gianello R, Jiang WJ, Ng FM

The peptide did not produce adverse metabolic effects associated with full-length growth hormone, including insulin resistance, glucose intolerance, or IGF-1 elevation