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Environmental factors, genetic predisposition, and smoking are significant contributors to the development of RA ( In recent decades, the incidence of RA has increased significantly, and this trend is expected to continue ( This chronic condition is characterized by inflammation of the synovial membrane, leading to joint damage, swelling, stiffness, pain, tissue degradation, deformity, and instability

[DOI] [PMC free article] [PubMed] [Google Scholar] Reynolds IJ, Hastings TG

Once the drug is present on the skin surface, it can diffuse through the epidermis through two routes, either transepidermal(transcellular or intercellular) or transappendageal(sweat ducts, hair follicles, and pilosebaceous glands) [311]

doi: 10.1093/qjmed/hcae070.352 69

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