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Br J Clin Pharmacol 42(6):713719 Matsunaga T, Kishi N, Higuchi S, Watanabe K, Ohshima T, Yamamoto I (2000) CYP3A4 is a major isoform responsible for oxidation of 7-hydroxy-Delta(8)-tetrahydrocannabinol to 7-oxo-delta(8)-tetrahydrocannabinol in human liver microsomes