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Additionally, the consumption of various food-derived antioxidants, such as vitamin C, might interfere with ROS-based anti-cancer strategies

Cardiac sirtuin1 deficiency exacerbates ferroptosis in doxorubicin-induced cardiac injury through the Nrf2/Keap1 pathway
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Over subsequent evolutionary periods to the present day, melatonin retained its ability to detoxify reactive ROS
In contrast to other GPxs, GPx4 is the only one that reduces the hydroperoxides of lipoproteins and complex lipids, such as cholesterol, cholesterol esters, and phospholipids [108], to protect mitochondrial ATP generation from oxidative damage [109]
