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So far, it has been described that when reduced by approximately 20%, the levels of ascorbate in cells or plasma inevitably favor the formation of lipid peroxidation products in the whole organism [111,112,113]

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indicates that the combination of both drugs, administered in low doses for 30 days to middle-aged men with impaired functional and structural characteristics of arterial walls, leads to an increase in the expression of Sirt1 (1.8 times), telomerase activity, the catalytic subunit of AMP 2 protein kinase (PRKAA) (1.5 times), and the KLOTHO gene (1.7 times) after just 30 days of treatment [132]

However, each of the four products can be oxidized to 3-ketosteroids with a concomitant double bond isomerization to give progesterone, 17-hydroxyprogesterone, androstenedione, and testosterone, respectively (Figure 7), and the alternative route to the sex hormones is named the delta4-pathway