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Moreover, such a small molecule could serve as a tool compound to interrogate the function of the ADP-ribosyltransferase tankyrase, which is proposed to expel TRF1 from shelterin, thereby promoting telomere extension 18,19,20,21

[DOI] [PMC free article] [PubMed] [Google Scholar] 233

Johns, M

May 31st, 2024 Understanding the Hormone FGF21 From regulating metabolism to supporting weight loss and improving heart health, learn the key role FGF21 plays in maintaining a healthy body and mind

However, some optimistic signs are dawning, with some recent works employing cutting-edge technologies such as patient-derived organoid culture and single-cell RNA sequencing, which have connected ASD development with the haploinsufficiency of epigenetic factors and chromatin remodelers (SUV420H1/KMT5B, ARID1B, and CHD8) [196], while the inhibition of LSD1 demethylase has been observed to reverse ASD phenotypes in mice [197]