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Kortam, Abdelrahman & Fateen, 2020

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Unlike other organelles such as mitochondria, where an abundance of reduced glutathione (GSH) preserves a reductive environment, the ER requires an oxidizing milieu to facilitate the formation of disulfide bonds critical for protein structural integrity

For example, enhancing oxidative phosphorylation in microglia might promote a more quiescent, neuroprotective state, while targeted inhibition of glycolysis could reduce harmful inflammation (Barros et al., 2009

AFADESI-MSI experiments The AFADESI-MSI platform mainly comprises a home-built AFADESI source, an ESI sprayer, a sample carrier platform, a 3D translational stage, a height-adjustable desk, and an electricity control module 50