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It has been shown that the use of different inhibitors to inhibit apoptosis, necrosis and autophagy is more effective than the use of any of these inhibitors in isolation, as in the case of cerebral hemorrhage, where caspase inhibitors have been shown to be unsuccessful in terms of inhibiting hemoglobin-induced neuronal death (142)

144 Considering these disadvantages, Kang et al screened a library of FDA-approved small molecule compounds and identified purpurin as a GDH1-selective inhibitor

Cayman Chemical offers a ferroptosis inducer that triggers the production of ROS likely through a dysregulated MVA pathway

GLP-1RAs in nervous system In the nervous system, GLP-1 can decrease oxidative stress and inflammatory responses, potentially through reducing the generation of ROS and decreasing the expression of inflammatory cytokines