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Effect of alpha-linolenic acid supplementation on cardiovascular disease risk profile in individuals with obesity or overweight: a systematic review and meta-analysis of randomized controlled trials

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Since ATF4 is known to work upstream of FGF21 as an early ISR effector, we also studied the metabolic phenotype of BAT-specific dual ATF4/PDSS2 knockout animals (DKO ATF4 ) (Appendix Fig

Allosteric regulation of ARs transcriptional activity The mechanistic insights reported above are consistent with allosteric regulation of transcription factor action, in which the type of DNA motif to which the factor binds and its protein and ligand interactions influence its conformational plasticity and the availability of tunable multimerization and protein interaction surfaces that control context-dependent and gene-specific transcriptional activity [78, 80]

Energy Metabolism