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Several large-scale population studies have identified an association between unexplained high B12 and the subsequent diagnosis of solid tumors

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Patients who have undergone gastric banding should be aware of the following signs that may indicate falling B12 levels and warrant prompt blood testing: Neurological symptoms: Tingling, numbness, or 'pins and needles' in the hands or feet Difficulty with balance or coordination Memory problems, difficulty concentrating, or 'brain fog' Mood changes, including low mood or irritability Haematological symptoms: Persistent fatigue or weakness disproportionate to activity levels Breathlessness on mild exertion Pallor or a slightly yellowish tinge to the skin Other indicators: A sore, smooth, or inflamed tongue (glossitis) Mouth ulcers occurring frequently It is important to recognise that some of these symptoms particularly fatigue and low mood are non-specific and may overlap with other post-operative nutritional deficiencies, such as iron or vitamin D deficiency

According to one report, 3% to 43% of older adults living independently may have low serum vitamin B12 levels, especially those with conditions such as atrophic gastritis or pernicious anaemia

Specific suppression of insulin sensitivity in growth hormone receptor gene-disrupted (GHR-KO) mice attenuates phenotypic features of slow aging