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Under normal circumstances, the redox system within cells is in dynamic equilibrium, with stable production and clearance of ROS

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Statements Author contributions AR: Data curation, Formal analysis, Investigation, Methodology, Validation, Writing original draft

(1985) Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

Future research should prioritize elucidating dynamic iron transport mechanisms across the blood-brain barrier, validating combination therapies targeting synergistic ferroptosis regulators (e.g., Nrf2/GPX4/FSP1), and advancing preclinical findings toward biomarker identification and precision intervention protocols