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identified the first covalent NNMT inhibitor 6 that reacts with a non-catalytic cysteine residue (C165) in the active site of NNMT to label NNMT in cell lysates

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This results in a wearing off phenomenon, and/or the restless legs begin earlier in the evening or even in the morning

[DOI] [PubMed] [Google Scholar] 186.Kopelman P, Groot Gde H, Rissanen A, et al
Combining Peptides for Maximum Results Strategic stacking multiplies benefits through complementary mechanisms
