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However, when the balance between pro-oxidants and antioxidants is adversely perturbed, redox stress, including oxidative stress and reductive stress, occurs (Fig
Walton, T., et al

In this study, ERO1A was down-regulated, whereas the expression of SEC63 was up-regulated at the protein level in response to riboflavin deficiency, suggesting that riboflavin deficiency impairs the oxidative folding and subsequent secretion of proteins in HepG2 cells

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Wu, Y., Wang, W., Diez-Sampedro, A
