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There is significant overlap in presentation across the three types, with no treatments that are specific to an individual type [1]

51, 102233 10.1016/j.redox.2022.102233 [DOI] [PMC free article] [PubMed] [Google Scholar] 136.Sun H.J., Wu Z.Y., Nie X.W

In a model of Nrf2 / null mice subject to partial ischemia and reperfusion, the expression of several Nrf2-dependent genes was compromised, including GSTm1, NQO1, and GCL, resulting in the worsening of the redox state in comparison with livers from wild-type mice [218]

Firstly, while microneedle technology is more advanced in skin and ocular drug delivery, its application in liver disease treatment requires further research, which undoubtedly increases the complexity of clinical translation for liver diseases

Verification: Pharmacokinetic reviews confirm that intranasal delivery utilizes the olfactory and trigeminal nerve pathways