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Apparently, the presence of cytosolic and mitochondrial forms is due to the presence of two mRNAs derived from the same gene coding for proteins, respectively, with and without mitochondria-targeting leader sequences (Malherbe et al., 1995, Mosca et al., 2003)

Interestingly, all-trans retinoic acid (ATRA), an inhibitor of Pin1, inhibits the drug resistance of cells mainly by inhibiting the ERK 1/2 and AKT pathways ( Inhibition of epithelialmesenchymal transition (EMT)-like phenomena is also a direction to take to overcome drug resistance

(2017) Cellular retinoic acid binding protein 1 modulates stem cell proliferation to affect learning and memory in male mice

Starzl in 1963

Glutathione is often called the bodys master antioxidant and for good reason