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Loss of extracellular matrix is in part due to death of fibrous cap smooth muscle cells, resulting from macrophage-derived Fas receptor ligand (195), inflammatory cytokines (196), and oxidation products (Figure 5) (197,198)
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In addition to PHGDH, serine hydroxymethyltransferase (SHMT) is also implicated in tumorigenesis
In the phase 3 ESSENCE trial, semaglutide significantly improved fibrosis without worsening steatohepatitis versus placebo, which is meaningful
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