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A deficiency can also cause issues such as diarrhea, nausea, vomiting, lack of appetite, weight loss, pale skin, numbness and tingling in your hands and feet, confusion, irritability, depression, and behavior changes

This effect was blocked by chlorpromazine, suggesting that this effect was driven by D2-like receptors, although the effect could be influenced by the many effects of chlorpromazine on nondopaminergic receptors (Yang, Anh et al., 2014)

Minor shaking rarely degrades the peptide significantly

Morphine promotes rapid, arrestin-dependent endocytosis of mu-opioid receptors in striatal neurons

In March 2025 it will be a year since the Nice Guideline on B12 Deficiency in over 16s was published
