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Also, administration of melatonin exerts hepatoprotective effects in a rat model of CPB( cardiopulmonary bypass model) and SIRS(systemic inflammatory response syndrome) by reducing the ROS generation which is well demonstrated in biochemical and histo-pathological experiments [57,58]

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Melling N, Kowitz CM, Simon R, Bokemeyer C, Terracciano L, Sauter G, et al

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It is also important to note that states of GH-excess, such as acromegaly, are associated with muscle weakness and fatigue (Flitsch, Spitzner and Ludecke, 2000), suggesting that chronically elevated levels of GH or IGF-I have a deleterious effect on muscle