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Consumption of alcohol by patients given therapeutic doses of disulfiram results in acetaldehyde accumulation, the physiological consequences of which include low blood pressure, tachycardia, facial flushing, nausea, and vertigo (Bell and Smith, 1949)

The COMT gene catechol-O-methyltransferase helps to break down and expel substances that have a catechol structure

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10.1016/j.biocel.2006.07.001 159
