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However, absence of thorough human clinical trial data means some uncertainty remains regarding long-term safety
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These include, extreme tiredness, a lack of energy, pins and needles, muscle weakness, disturbed vision, mouth ulcers, a sore and red tongue, and cognitive or psychological concerns such as depression, confusion, and difficulty with memory, understanding or judgement
Increased matrix metalloproteinase-9 (MMP-9) activity observed in chronic wound fluid is related to the clinical severity of the ulcer
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