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These findings support TDP-43 dysfunction and altered m6A modification converge to drive alternative splicing defects in HD (Nguyen et al., 2025)

In addition to being synthesized by cardiomyocytes and known to modulate vascular permeability and dilation/constriction, NPPC is also produced locally by Sertoli cells in the testis and serves in an autocrine manner (80)
Heine, A., Juranek, S
Vogt et al., 2021

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