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Importantly, tirzepatide carries a boxed warning for risk of thyroid C-cell tumors, including medullary thyroid carcinoma (MTC), and is contraindicated in patients with a personal or family history of MTC or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)

Notably, caRNA sequencing (caRNA-Seq) revealed a more than fivefold higher occupancy of reads in intronic, exon/intron junction and intergenic regions compared with poly(A) + RNA (Fig

PMID 29208439

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