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The available evidence suggests that high doses of opioids drugs might impair several aspects of mathematical skills, including the speed at which participants complete oral and written addition tasks as reported by Smith and colleagues (Smith, Semke, & Beecher, 1962)

So if you took B12 and felt worse, and your blood B12 is elevated, and you have a constellation of symptoms across multiple systems that's three signals pointing toward MCAS as worth ruling out

10.1111/j.1365-2982.2010.01620.x 342 NiccolaiE.MartinelliI.QuarantaG.NanniniG.ZucchiE.De MaioF.et al

et al., 2024), understanding how xenobiotics disrupt gutbrain communication is urgently needed