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N-acetylcysteine reduces the exacerbation rate in patients with moderate to severe COPD

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HO-1 expression is also involved in protection against acute kidney injury (Ramos et al., 2019) and acute lung injury (Pereira et al., 2016) that occur in mice during Plasmodium infection, indicating that heme may play a role in mediating various malarial complications

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ROS derived from the Nox subtypes Nox1, Nox2, and Nox4 lead to vascular dysfunction in diabetic retinopathy, and Nox5-derived ROS increase the incidence of abdominal aortic aneurysms in diabetic patients [16, 17]