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PGC-1, a pivotal regulator of mitochondrial biogenesis and cellular resistance to oxidative stress, plays a pivotal role in the function and survival of dopaminergic neurons in the substantia nigra (Halling and Pilegaard, 2020)

Individuals with T2DM taking tirzepatide, a dual GIP and GLP- 1 receptor agonist, experienced better weight loss and blood sugar control than patients taking GLP- 1 receptor agonism

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Consequently, the authors claim that the initiation of supplementation with high doses of antioxidant agents at the diagnosis of diabetes does not demonstrate the effectiveness of preserving beta cell function or metabolic balance

Birtwistle L, Chen X-M, Pollock C