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Impaired cell signaling pathways also disrupt this cycle, and once this happens, pigment can no longer be regenerated, leading to permanent greying

AmorimSTeixeiraVHCorredeiraRCunhaMMaiaBMargalhoPet al

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An elevated level of AChE metabolises more acetylcholine and decreases its level in the synapses and then disturbs cholinergic neurotransmission, which results in memory impairment (8)