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Studies have shown that the redox couples cysteine/cystine (Cys/CySS) and Trx (SH)2 [reduced Trx/TrxSS] [oxidized Trx], as well as GSH [reduced glutathione] and GSSG [oxidized glutathione] are critical components of the thiol/disulfide redox system (Circu and Aw, 2011) (Figure 3)

Association between thyroid autoimmunity and fibromyalgic disease severity

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Wilkinson HA, Dahllund J, Liu H, et al
Oral supplements are usually the first choice, but injectable B12 might be needed for severe cases