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Regulatory scrutiny also targets unapproved compounded formulations due to dosing inaccuracies, contamination risks, impurities, inconsistent potency, and use of unapproved salt forms, contributing to hospitalizations and other serious outcomes

Potential CLA-Related Health Risks The main reason we cant recommend the use of CLA as a dietary supplement is because of the numerous health risks associated with its use

Male rats also had higher circulating estradiol and leptin but lower IGF-1 levels, while female rats had lower progesterone and IGF-1 levels compared to control groups (531)

This leads to depolarization of the postsynaptic cell, which enhances neuronal excitability (55)

Journal of Drug Targeting (2018)