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Although their precise functions are unclear, microRNAs, long non-coding RNAs, histone modifications, and DNA methylation most likely regulate the inflammation and neurodegeneration associated with COPD [105]

Although the underlying molecular pathways remain unclear, recent studies have implicated picrosides (iridoid glycosides in P kurroa extracts) in activating Nrf2 pathways, leading to the increased expression of detoxifying enzymes (Soni and Grover, 2019)

doi: 10.1016/j.colsurfb.2010.12.021

Br J Dermatol 179(3):570581