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NAC has the potential to reverse the activation of the NLRP3 inflammasome as shown in, e.g., LPS-exposed H9C2 cardiomyocytes [219], in macrophages exposed to carbon nanotubes and silica [220], in bisphenol S-induced oxidative stress in murine RAW264.7 cells [221], or in cells infected by SARS-CoV-2 [222], thereby representing additional therapeutic targets for NAC

doi: 10.1038/s41586-023-06017-4 53 RuizLMLibedinskyAElorzaAA

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