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In a randomized clinical trial, tesamorelin reduced visceral adipose tissue and liver fat in HIV-infected patients (Stanley et al., JAMA, 2014), and its Phase 3 program (Falutz et al.) established the visceral-fat effect that underpins its FDA approval

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[DOI] [PMC free article] [PubMed] [Google Scholar] 55.Liu BY, Xue JL, Gu QQ, et al

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Currently, the relationship between muscle damage, oxidative stress and other systems of proteolysis such as apoptosis are poorly understood