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Autophagy relies on formation of different membrane structures to engulf and destroy cargos (including proteins and organelles), whereas the UPS is mainly carried out to degrade proteins through a hierarchical enzymatic cascade

suggests that TB-500 may interact with cell movement as it binds globular actin (G-actin) and may modulate how actin filaments assemble to plausibly make endothelial cells more able to change shape, migrate, and form multicellular structures

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In terms of their chemical nature, QSIs can be classified as natural products, synthetic molecules and antibodies (Table 3)