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As a result, the dose to be administered to gain appreciable uPA/uPAR inhibition in vivo might be higher than can be tolerated in humans, which reduces clinical translation [171, 173]

Drug Des Devel Ther 9:24852499 Vukojevic J, Siroglavic M, Kasnik K, Kralj T, Stancic D, Kokot A et al (2018) Rat inferior caval vein (ICV) ligature and particular new insights with the stable gastric pentadecapeptide BPC 157

Rev Endocr Metab Disord 2015

Younger patients often have better outcomes with both treatments, but stem cell therapy may be particularly effective for those under 60
