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The cumulative permeation amount is a key parameter when evaluating drug delivery efficiency, which can be calculated using the following equation (1) (details of the parameters are given in the Material and Methods section): The calculated results (shown in Fig

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Nevertheless, although the differences in the metabolic states of M1 and M2 are well accepted, the underlying mechanisms involved in switching between metabolic states are not well understood

Some doctors recommend using progesterone for half the month only (luteal phase) in pre-menopausal women, while other doctors recommend using it all month long except while menstruating
