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Thus, additional research is required to develop protocols for screening, prevention and treatment of metformin-induced vitamin B12

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The ALDH2*2 polymorphism results in a deficient ALDH2 isoform with a very low capacity for acetaldehyde metabolism

Histological analysis by H&E staining, measurement of epidermal thickness, and immunostaining were performed by Inotiv Boulder (Boulder, CO) with the Leica Bond RX/RXm platform using standard chromogenic methods or by Dallas Tissue Research (Farmers Branch, TX)

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