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This interconnectivity means that chronic pain in comorbid conditions is often multimechanistic, involving concurrent elements of nociceptive (e.g., joint damage in obesity), neuropathic (e.g., nerve compression in cancer, metabolic injury in diabetes), and nociplastic (e.g., central sensitization fueled by systemic inflammation) pain

The enzyme should be inactivated and/or removed from the sample after cleavage

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Novel haemodialysis (HD) treatment employing molecular hydrogen (H(2))-enriched dialysis solution improves prognosis of chronic dialysis patients: a prospective observational study