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Melatonin can directly scavenge ROS through its electron-rich indole ring, and it can also induce antioxidant enzymes such as GPX, SOD, and catalase to achieve antioxidative effects

In vivo evaluation demonstrated that mice tolerated LAAM GSH-CQDs at doses up to 5000 mg kg 1 , compared to 18 mg kg 1 for LAAM TC-CQDs, 12 mg kg 1 for Lipo 2000, and 16 mg kg 1 for GO-CQDs

Morrow et al., 2007

However, patient experience is mixed: while some members report no difference between the two methods, others find they do not achieve the same symptom resolution with SC injections

Studies have found that Epitalon restored melatonin formation in the pineal body of older monkeys, increased superoxide dismutase (SOD) activity, and reduced the amount of LPO products, diene conjugates, and ROS [23, 33, 34]