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Shikonin promotes ferroptosis in HaCaT cells through Nrf2 and alleviates imiquimod-induced psoriasis in mice

Retatrutide is a therapeutic peptide that should only be used under medical supervision

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These data demonstrate that FDX1 is essential for emodin to induce copper overload, antioxidant collapse, and subsequent cell death, providing direct genetic evidence that emodin triggers cuproptosis specifically via an FDX1-dependent pathway

Immunofluorescence Fibroblast cultures at passage 3 were cultured in eight-well chamber slides (Gibco, Burlington, ON, Canada) in growth medium (DMEM, 10% fetal bovine serum (FBS), penicillin, and streptavidin from Invitrogen, Burlington, ON, Canada)