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Fernandez, C

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These findings should be overseen with glutamate as the major excitatory neurotransmitter in the central nervous system (i.e., cognitive functions such as learning and memory in the brain [200], the precursor of major inhibitory neurotransmitter GABA) but excitotoxic neuronal death as a direct result of high concentrations [201], and tight physiologic range that should be maintained [59]

Until there is direct comparative data, route selection should be driven by clinical context and patient preference, not assumptions about delivery superiority

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