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Description
Among elderly patients belonging to the Framingham cohort, Lidenbaun [9] observed a prevalence of over 5.3%

When NF-kB activity is elevated, cells may produce more inflammatory signals such as TNF-alpha, IL-6, IL-8, and related mediators
Compressed timelines (doses every 35 days) did not improve outcomes and increased markers of systemic inflammation
The 2025 Kokkorakis pharmacology review framed the combined-formulation research within the emerging-pharmacotherapy landscape (PMID 39952695)

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