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Both H 2 O 2 and 3Ac-AP contribute to oxidative stress as a result of polyamine catabolism

26 FuP.LiuJ.BaiQ.SunX.YaoZ.LiuL.et al (2020)

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These findings raise awareness not only about the cytotoxic effects of the drug but also about its potential to contain the spreading of cancer by reducing invasion and migration ( 4.5 Taxanes, molecular cascades, and targeted signaling pathways Overall, paclitaxel inhibits the activation of Akt (downstream effector of the PI3K pathway), thus reducing the phosphorylation of mTOR and decreasing cell proliferation at the expense of increased cell death

10.1007/s10142-007-0045-8 119 PascalS.ScallaR