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(PubMed) van Wijngaarden JP, Doets EL, Szczecinska A, et al

25 A benzimidazole analog ( 3 ) also showed an IC 50 value of 16.7 6.4 M, but the benzothiazolium scaffold lost the inhibitory activity (Fig

The enzyme methionine synthase needs methylcobalamin as a cofactor

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Neelakantan and colleagues (Biochem Pharmacol, 2017) then took the pharmacological step, reporting that selective, membrane-permeable small-molecule NNMT inhibitors reversed high-fat-diet-induced obesity in mice this is the study most directly relevant to the 5-Amino-1MQ class, because it moves from the target matters to a drug against the target does something in a live animal. And again, it is a mouse study