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The Leyden 2002 clinical evaluation in the Journal of Cosmetic Dermatology compared a copper tripeptide cream and serum against placebo in 67 women with photodamaged skin and found significant improvements in wrinkle depth, skin laxity, clarity, and density at 12 weeks [30]
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Recent data suggest that the non-canonical inflammasome pathways play critical roles in acute lung injury and sepsis by sensing cytosolic LPS (41)
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