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It begins below the obesity-trial floor because appetite and gastrointestinal effects need time to adapt before escalation
Mild, transient fluid retention/edema and joint or muscle pain, each reported more often on MK-677 than placebo in the same trial, linked to elevated GH and IGF-1
Contamination, incorrect dosing, and degradation are real possibilities
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doi: 10.1016/j.jpeds.2012.04.046
